The month of October is Pink from start to finish. However, this Saturday (19) takes on even stronger shades of color and its meaning, as it is remembered as World Breast Cancer Day.
And although scientific research on this type of tumor is carried out and published every month, there is greater concern about publishing studies on the topic during this period. Therefore, we have gathered some studies released in recent days that bring good news about treatment, diagnosis and other topics related to breast cancer. Check it out below:
1. New therapeutic strategy may treat more difficult breast cancer
Triple negative breast cancer is considered the most aggressive and deadly type, but research from Mass General Brigham, published in the journal Nature showed that combining two types of therapeutic agents selectively kills cancer cells.
The saviors in question are agents known as EZH2 and AKT inhibitors, which can induce cells in this type of cancer to differentiate. “When combined, these therapeutic agents can hijack naturally occurring signals in the body to eliminate breast cells after the cessation of lactation to kill these aggressive cancer cells,” said lead author Karen Cichowski, PhD, of the Division of Genetics at Brigham and Women’s Hospital ( BWH) in the disclosure note. But the study was done with patient samples in vitro and still need to be evaluated in clinical trials.
2. New regulator may bring more treatment possibilities for this same type of tumor
Researchers found that an enzyme called DAPK3 protein is present at higher levels in triple-negative breast cancer cells than in normal cells. They also realized that DAPK3 promotes the migration and invasion of his cells, which could enable new treatments. THE study was done by scholars at Baylor College of Medicine and published in the prestigious scientific journal PNAS Nexus.
3. YouTube content can help patients cope with a breast cancer diagnosis
Researchers from the Faculty of Social and Communication Sciences at the University of the Basque Country studied a playlist of 1,247 videos about breast cancer from around the world on the YouTube video network, aiming to identify those with the greatest communication power and map the concerns of people who post comments on them.
Analysis of comments on YouTube videos showed that the vast majority of them “focus on appreciating the valuable information they provide,” as researcher from the university’s Department of Journalism, María Ganzabal, said. She realized that this “is a very grateful community, there is a lot of sense of sisterhood, a lot of support and little hateful or malicious content.” She emphasized the importance of personal stories “as a source of hope and support for those who have been affected by the disease.”
4. Drug may be a promising treatment option for metastatic breast cancer
The DESTINY-Breast12 study looked at the effectiveness of a new drug, trastuzumab deruxtecan (T-DXd), in patients with HER2-positive metastatic breast cancer. The main focus was on patients with and without brain metastases. The results of studypublished in Nature Medicine, indicate that T-DXd is a promising treatment option for patients with HER2-positive metastatic breast cancer, regardless of the presence of brain metastases. Its efficacy and safety profile make it a valuable addition to the treatment of this type of cancer.
5. New drug can treat complex diseases such as breast cancer
The substance can actually be used for more conditions, such as diabetes, but it has been successfully tested on breast cancer cells. THE study was conducted by researchers at the University of Barcelona and published in the scientific journal Bioorganic Chemistry.
The medicine is a compound of three antisense oligonucleotides (ASOs), which are short chains of nucleic acids designed to bind to specific messenger RNAs and thus block the key function of this molecule in protein synthesis in cells. It was able to inhibit the expression of three specific proteins (Akt, Hsp27 and HER2), which contribute to the poor prognosis of breast cancer and drug resistance.
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This content was originally published in Combating Breast Cancer: check out 5 scientific news launched in October on the CNN Brasil website.
Source: CNN Brasil

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