Genetic skincare: the key to slowing aging

The path of personalization in the beauty world leads to tailor-made skin care based on DNA. A completely new way that involves a scientific approach. Researchers have long pointed out that genes also contain information to stop skin aging. Thus was born the first generation of genetic creams that simply seek to protect cellular DNA.

THE AGING POINT
However, research shows how it is possible to go even further to find the genetic decay point of the skin and delay it.

The key is the critical point of the skin which, like all the organs of the body, has its crucial moment of aging. The goal is to delay this tipping point, perhaps indefinitely. With their research, scientists discover that skin ages, but genetic information does not. In other words, the genetic information needed to keep skin in optimal health is more difficult to obtain as we get older. For the skin to remain young it is necessary to increase its ability to receive genetic messages. Lancôme took an important first step by identifying two of the markers responsible for slowing down genetic information and with Génifique accelerated the speed of genetic information to the skin. A discovery with very powerful implications for future anti-aging products, so much so that many other products are born that use genetic technology to delay the aging point.

ACTIVATION OF SIRTUINS
There are several genes that have a huge impact on the skin. Estée Lauder’s research labs first focused on activating the famous skin longevity gene, sirt-1. They also later discovered that all sirtuins (proteins that increase longevity) are essential for the activity of skin cells. Activating sirtuins with specific ingredients can have a big impact and increase the activity of skin fibroblasts to help fight aging. There is mounting evidence showing the importance of sirtuins in longevity, metabolism and stress control. Sirtuins are evolutionarily well-preserved proteins found in mammalian cells, where they help maintain energy levels, control inflammation, and support repair. Over the years, the Estée Lauder group has made a lot of progress in understanding the importance of sirtuins (also called longevity proteins) in keeping skin functioning well. Estée Lauder’s research shows that by combining sirt-1, 3 and 6 activators and treating mature skin cells, it is possible to reverse their aging profile and restart their protein mechanism such as collagen production.

GENETIC SKINCARE
Scientific research is going even further to come up with a new skincare that harnesses genetic information. To better understand this research it should be remembered that all biological reactions of the body are controlled by our genes (estimated between 25,000 and 30,000). Any product applied to the skin is immediately followed by a response from genes, which can be activated or inhibited. By following the activity of certain genes, we can then read, at a given moment, what is happening inside the skin. It is possible to contact fragments of DNA with a cosmetic active ingredient and analyze which genes turn on or off. This gives a good idea of ​​what will happen in vivo when the product is applied to the skin. Thanks to genomics (the biological discipline that studies the organization and structure of the genes of an organism), however, it is possible to obtain an overview that allows to optimize the effectiveness of the active ingredients. Creams designed according to the laws of genomics have truly demonstrable effects. However, not all products on the market are tested in this way yet.

BEAUTY DA NOBEL
Scottish by birth and American by adoption, Sir (since 2006) Fraser Stoddart, received the Nobel Prize in Chemistry in 2016, thanks to his discovery of the Organic Super Molecular Vessel technology, a molecular transport mode that can be used in many sectors , from personal care to pharmaceuticals, from food to petrochemicals. This technology is the basis of Noble Panacea, the skincare brand created by Stoddart. OSMV is used as a base to transport active ingredients such as retinol and teprenone (a cell-activating molecule that is believed to help stabilize telomeres, the structures found at the ends of our DNA strands) into the cell, exactly where they are needed and at the right time. Unlike most delivery systems, OSMV does not bomb the skin with all the active ingredients in one go, but the integrity of each ingredient is protected and also made more effective.

“Using OSMV technology as a basis, in vitro experiments show how the effectiveness of the regenerative and healing properties of active skin care ingredients is increased tenfold – comments Stoddart – If you give your skin time to absorb the active ingredients instead of throwing them out. too many all at once, they will arrive when the skin is ready to absorb them ».

OSMV’s ability to host and protect active ingredients at the molecular level allows for multiple ingredients to be combined without cross-interactions. For this OSMV can be programmed for a precise and controlled release of ingredients directly into the cells where they release their full potency. Working collaboratively, scientists and researchers from Noble Panacea’s research and development team and Northwestern University’s Stoddart Research Group have the best experience and technology in the industry, allowing them to explore the effectiveness of skincare with unprecedented precision. and cutting-edge innovation. So no effects that fade after half an hour: with OSMV technology, the products can still act for 24 hours.

“Only active ingredients proven for skin health, optimized by our programmed OSMVs are included in our products,” explain the Noble Panacea researchers. «As a final step, the effectiveness of our products is evaluated and validated by dermatologists and ophthalmologists. We design highly effective, responsible and environmentally friendly skincare products that are completely transparent in creation ».