Researchers at Mayo Clinic, a non -profit organization of reference in clinical practice, education and research, have discovered a new target of immunotherapy that can help the immune system combat the ovary cancer . The news was recently published in Sciences Advances.
Ovarian cancer is the third most common gynecological tumor type in Brazil, behind cervical and endometrium cancer, according to the National Cancer Institute (INCA). Initially, the disease does not generate symptoms, which can make it difficult to diagnose early and, consequently, the chances of more successful treatment.
The new target of immunotherapy discovered by the researchers is a cryptic antigen, which is part of a protein – called epitopes – which is usually hidden or inaccessible to the immune system and may be present in tumor cells. When immunotherapy affects these antigens, the immune system can be effectively mobilized to attack cancer.
“These findings highlight the need to explore alternative sources of target antigens to ovarian cancer,” says Marion R. Curtis, senior author of the study and immunologist at the Mayo Clinic Integral Cancer Center. “Discovering antigens associated with tumor that cells recognize is crucial to the success of immunotherapeutic approaches in ovary cancer, where the growth of ovarian cells multiply quickly and can invade and destroy healthy body tissues.”
T cells are part of the immune system and act to recognize infected or carcinogenic cells and attack them, fighting tumors and infections.
The researchers characterized tumor antigens generated from ovary cancer using multi -comic approaches to determine their ability to trigger an immune response. The term “multi -comic” involves the use of multiple “omas” (ie, genome, proteoma, microbioma, epigenoma) to better understand the mechanisms of disease, detection, possible preventions and more directed therapies.
The next steps involve preclinical tests and clinical trials to evaluate the safety and effectiveness of new immunotherapies and vaccines that target these cryptic antigens. Researchers also plan to conduct higher -scale studies to evaluate the prevalence of critical antigens’ expression in different tumors, thus enabling the expansion of applications of this immunotherapeutic approach.
Endometriosis increases risk of ovarian cancer by four times
This content was originally published in new ovarian cancer therapy is identified under study; Understand on CNN Brazil.
Source: CNN Brasil
I am an experienced journalist and writer with a career in the news industry. My focus is on covering Top News stories for World Stock Market, where I provide comprehensive analysis and commentary on markets around the world. I have expertise in writing both long-form articles and shorter pieces that deliver timely, relevant updates to readers.
