Recently, through a study published in the journal Naturethe investigation of some American scientists was released, who assure that the protein of the liquid of a molecule in the brain helps to rejuvenate it and recover memory, so it could be the beginning of the cure against Alzheimer’s.
The research was carried out by Stanford University, in California, United States, where they carried out the relevant tests on mice, which resulted in the fact that the young liquid protein called Fgf17 is capable of rejuvenating old brains, as well as preventing the loss of memory and even recover it.
According to the published study, the scientists discovered that the Fgf17 protein is capable of stimulating the production of young oligodendrocytes, which are part of the white matter of the brain, which supports the gray matter, where the neurons are found.
We found that fibroblast growth factor 17 (Fgf17) infusion is sufficient to induce OPC (oligodendrocyte progenitor cell) proliferation and long-term memory consolidation in aged mice, whereas Fgf17 blockade affects cognition in young mice.
– Explain the study
This discovery could be a breakthrough in the fight against Alzheimer’s, since it could not only be prevented, but could also be a good treatment for patients to recover their memory.
The tests consisted of extracting cerebrospinal fluid from both two-and-a-half-month-old mice and one-and-a-half-year-old mice to compare the results. These showed that 38 proteins of this liquid change significantly with aging, while another six are related to cognition or markers of Alzheimer’s in humans.
The results offer a therapeutic strategy to prevent or reverse cognitive decline associated with age and neurodegenerative diseases. We found that infusing young CSF (cerebrospinal fluid) directly into aging brains improves memory function.
– Steven Shuken, researcher who participated in the study
According to what was seen in the studied mice, the old ones forgot a simple sequence, which consisted of a light that turns on and then receives an electric shock, while the young ones became alert after they saw the light, since they remembered that followed by that came the download.
This study not only implies that Fgf17 has potential as a therapeutic target, but also suggests that drug delivery routes that allow therapies to directly access the cerebrospinal fluid could be beneficial in the treatment of dementia.
– Miriam Zawadzki and MarÃa Lehtinen, study researchers
The research opens the way to a new opportunity in the field of brain health. Although work has not yet begun on a drug to slow cognitive decline in the brain, it could be the first step in finding a possible treatment for neurodegenerative diseases such as dementia and Alzheimer’s.
Source: Okchicas
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