Have a DNA sample taken at birth or within the first six months, through a saliva sampleallows you to analyze the changes, discover the genetic history and therefore be able to act in a targeted way in case of need.
In fact, fetal DNA is PURE in its original structure and without all the changes that will accumulate on it over time. PURE DNA represents an important starting point for comparative genetic analyses useful for understanding the changes that our DNA has undergone during life.
What happens to DNA throughout life
External agents such as stress, pollution, wrong nutrition have an impact on our body even going to change our DNA.
These DNA modifications caused by pollutants influence the turning on or off of some genes rather than others, paving the way for heart and respiratory diseases, as confirmed by research conducted in Canada by the Ontario Institute for Cancer Research group led by Philip Awadalla and published in the authoritative scientific journal Nature Communications.
One way to protect ourselves from these changes with important consequences on our health is represented by preservation of DNA at birth which allows us to protect this enormous biological heritage.
What is comparative DNA analysis for?
In case of diseases, having pure DNA available allows an analysis and comparison with the current state of the DNA, identifying in detail where there have been changes in order to be able to act accordingly in a targeted way with a suitable treatment plan.
DNA is also used in what is called “precision medicine” by using information about a person’s genetic make-up to formulate patient-dependent therapies. In the near future, physicians will be able to use genetic makeup information on a regular basis to choose drugs and tailor their doses depending on the patient thus obtaining greater therapeutic results.
One of the most common cases involves resistance to antibiotics which according to data from the Istituto Superiore di Sanità, it could cause the death of 10 million people a year by 2050 thus making it a truly pressing problem requiring global intervention.
«The investigations for the identification of the suitable drug are carried out, for example, on people infected with the human immunodeficiency virus (HIV). – explains the Dr. Stefania Fumarola, biologist and chief scientist at In Scientia Fides- Before prescribing the antiviral drug abacavir (Ziagen), doctors routinely test HIV-infected patients for a genetic variant that makes them more likely to have a negative reaction to the drug. Another example is the drug for the breast cancer trastuzumab (Herceptin) or even for the acute lymphoblastic leukemiaa, in such cases the US Food and Drug Administration (FDA) recommends genetic testing before administering the chemotherapy drug mercaptopurine (Purinethol)».
The FDA also advises doctors to test patients suffering from colon cancer for certain genetic variants before giving irinotecan (Camptosar), which is part of a combination chemotherapy regimen.
«Studies have found that the chemotherapy drugs, gefitinib (Iressa) and erlotinib (Tarceva), – concludes Dr. Fumarola – they work much better in lung cancer patients whose tumors have a certain genetic change. Furthermore, recently, researchers have identified genetic variations that influence the response of depressed people to citalopram (Celexa), a widely used class of antidepressant drugs called selective serotonin reuptake inhibitors (SSRIs). Being able to analyze the DNA and identify the mutation allows significant developments in precision medicine and enormous improvements in patient care through therapeutic plans adapted to each individual”.
Until recently, drug developers used an approach that involved screening chemicals with broad action against a disease. Researchers are now using the genomic information to find or design drugs that target subsets of patients with specific genetic profiles. The goal is to produce new drugs that are highly effective and do not cause serious side effects.
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Source: Vanity Fair
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