American doctors have assessed the effectiveness of Moderna and Pfizer-BNT RNA vaccinations in preventing COVID-19 symptoms no longer in clinical trials, but in real conditions of mass vaccination of the US population. A preprint (not yet peer reviewed report) is available on medRxiv.
The report was compiled by experts from the Mayo Clinic network using an artificial intelligence-based software platform from the nference company. Algorithms of the latter allow synthesizing disparate biomedical data for analysis and making them suitable for calculations.
The sample was made from physicians and residents of long-term care facilities in the states of Arizona, Florida, Minnesota and Wisconsin who were vaccinated in the first stage (between December 1, 2020 and February 8, 2021).
The authors compared 31,069 people who received at least one dose of any vaccine versus exactly the same number of unvaccinated people (matched predisposition based on demographic data, location and number of previously performed PCR tests).
“8041 people received both doses and were at risk of infection for at least 36 days after the first dose. 88.7% effective in preventing infection with onset at least 36 days after the first dose, “they write.
In the “vaccine” group, 263 people (0.85%) caught the infection over the established period, among the unvaccinated – 661 (2.11%).
In addition, those vaccinated who was then diagnosed with COVID-19 had significantly lower two-week hospital admissions rates than unvaccinated patients. Among the patients in the “vaccine” group, 7 people were sent to the hospital, among the unvaccinated – 217.
The authors’ conclusion is unambiguous: the study results “demonstrate the real effectiveness of vaccines in reducing the incidence of SARS-CoV-2 infection and the severity of COVID-19 among those at highest risk of infection.”
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